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KMID : 1134820070360050521
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Journal of the Korean Society of Food Science and Nutrition
2007 Volume.36 No. 5 p.521 ~ p.526
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Antioxidant Effects of Red Ginseng Powder on Liver of Benzo(α)Pyrene?Treated Mice
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Kim Hyun-Jeong
Lee Ji-Won
Ji Young-Ju
Yu Me-Hee
Park Jung-Hyun
Lee Ki-Dong
Lee In-Seon
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Abstract
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The effects of red ginseng powder on hepatotoxicity in benzo(α)pyrene [B(α)P]-treated mice were investigated. Male ICR mice were pretreated with red ginseng powder (50 or 100 ㎎/㎏/day, for 5 days, intraperitoneally) before treatment with B(α)P (0.5 ㎎/㎏, i.p, single dose). The ability of red ginseng powder to protect against oxidative damage to the mouse liver was examined by determining the level of lipid peroxide, glutathione, and the antioxidant enzyme activities. The glutathione content depleted by B(α)P were significantly increased by red ginseng powder, but elevation of lipid peroxide content induced by B(α)P was decreased by red ginseng powder. The increased activities of superoxide dismutase, catalase and glutathione peroxidase after B(α)P-treatment were decreased by the treatment of red ginseng powder; however, glutathione S-transferase activity depleted by B(α)P were significantly increased. These results suggest that red ginseng powder can protect against B(α)P intoxification through its antioxidant properties.
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KEYWORD
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red ginseng powder, B(α)P, hepatotoxicity, antioxidant activity
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